Fluoroquinolone toxicities is an effect of antibiotics which may cause long-lasting, serious adverse side consequences. They include nausea vomiting, diarrhea, and muscle pain. Floxing is also a reference to this.
Patients who have suffered side effects of the fluoroquinolone/quinolone antibiotic must avoid fluoroquinolones. A special consideration should be given when a patient is elderly, with kidney disease and patients who have undergone an organ transplant.
Nearly all quinolone antibiotics that are used are fluoroquinolones which have a fluorine element in their chemical structure and can be effective against Gram-negative and Gram-positive bacteria.
Fluoroquinolones “kill bacteria” by blocking enzymes which normaly break up DNA as cells replicate. They typically cut DNA’s double-helix and pass another part through the gap to complete the cut.
However, quinolones attach to enzymes, which prevent them from mending their wounds. In the 80s, scientists added fluorine atoms to molecules of quinolones. This allowed antibiotics to penetrate all tissues of the body as well as the central nervous system. It also increased their efficacy against a wide spectrum of bacterial infections.
Fluoroquinolones can be useful in certain conditions, including life-threatening, when other antibiotics are not sufficient to treat the problem.
But, fluoroquinolones are often overused like many antibiotics. They’ve been linked to serious side effects over the years. The FDA has issued numerous warnings on their usage. Many label changes have been required, and some fluoroquinolones even come with black-box warnings.
Which antibiotics can be called fluoroquinolones
These medications include Cipro (Cipro), Gemifloxacin(Factive) Levofloxacin/Levaquin Norfloxacin/Noroxin Cipro (Cipro), Cipro (Cipro), Cipro (Cipro), Cipro (Cipro), Cipro (Factive), Levofloxacin/Levaquin) Levofloxacin/Levaquin) Levofloxacin/Floxacin/Floxin (Floxin) and ofloxacin/Floxacin/Floxin (Floxin (Floxin), Cipro) gemifloxacin/Floxin (Floxin) and ofloxacin/Floxacin/Floxin (Floxin), Aveloxacin), and ciprofloxacin).
What is fluoroquinolone toxic syndrome?
Signs + Symptoms
There have been some serious side effects linked to fluoroquinolones. This includes long-term and permanent disabilities. Ciprotoxicity symptoms also include:
– Damage to mitochondria and DNA
– Brain fog
– Peripheral Neuropathy
– Blurry Vision
– DNA Damage
– Gaba and Gut damage can trigger anxiety and depression.
– Tendonitis
– Muscle Atrophy
– Reflexes are heightened
Ciprotoxicity signs include low back pain, tendonitis and tendon rupture and arthralgia. Fluoroquinolones could increase the risk for developing peripheral neuropathy by 47% over time.
Ciprofloxacin has been found to alter the topology of the mtDNA as well as inhibit normal maintenance and transcription mitochondrial DNA. Tendinitis and rupture of the tendon could be the result of damages to the mitochondria of tenocytes caused by fluoroquinolone treatment. It can also lead to fatigue, and inflammation.
For more information, click fluoroquinolone toxicity treatment